SCIENTIFIC PROGRAM – ORAL PRESENTATIONS

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ORAL PRESENTATION SESSION ABSTRACT CODE ABSTRACT TITLE
01 Colorectal Cancers 186 EVALUATION OF RKIP EXPRESSION AND KRAS/BRAF MUTATIONAL PROFILE OF ANAL TUMORS
419 OUTCOME OF INITIAL SCREENING FOR LYNCH SYNDROME IN CHINESE PATIENTS WITH COLORECTAL CANCER
315 COORDINATED MINIMALLY-INVASIVE MULTI-STAGE SURGERY FOR STAGE IV COLORECTAL CANCER
484 SEARCHING FOR NEW CANDIDATES GENES IN PATIENTS SUSPECTED OF LYNCH SYNDROME
98 ABERRANT ACTIVATION OF USP22 IS CRITICAL IN COLORECTAL CANCER PROGRESSION
02 Genitourinary Cancers 328 INTEGRATIVE METHODOLOGY TO UNCOVER DRIVERS CANDIDATES ASSESSING GENOMIC, TRANSCRIPTOMIC, MIRNA AND METHYLATION DATA IN PENILE CARCINOMA.
616 THE CLINICOPATHOLOGICAL SIGNIFICANCE OF MONOCARBOXYLATE TRANSPORTERS (MCTS) IN GERM CELL TUMORS
606 CLINICAL SIGNIFICANCE OF PD-L1 PROTEIN EXPRESSION AND TUMOR INFILTRATING LYMPHOCYTES IN LOCALIZED BLADDER CANCER
65 ESTABLISHMENT OF TUMOR VASCULATURE BY TUMOR CELLS IN CLEAR CELL RENAL CELL CARCINOMA
374 A RETROSPECTIVE COMPARATIVE STUDY OF SODIUM FLUORIDE (NAF-18)-PET/CT AND FLUOROCHOLINE (F-18-CH) PET/CT IN THE EVALUATION SKELETAL METASTASES IN METASTATIC PROSTATE CANCER USING A VOLUMETRIC 3-D ANALYSIS
108 CYBERKNIFE (CK) FOR PROSTATE CANCER PATIENTS – EARLY RESULTS OF 400 PATIENTS RADIOABLATION
03 Hematologic Diseases 453 PATHWAY ANALYSIS IN PH-NEGATIVE MYELOPROLIFERATIVE NEOPLASMS AND MYELODYSPLASTIC/MYELOPROLIFERATIVE NEOPLASMS BY WHOLE EXOME SEQUENCING
580 WEIGHT GAIN DURING THE FIRST 10 DAYS POST TRANSPLANTATION IS A RISK FACTOR FOR MORTALITY IN BOTH AUTOLOGOUS AND ALLOGENEIC STEM CELL TRANSPLANTATION
37 MICRORNA-494 ACTIVATION OVERCOMES THE DRUG RESISTANCE OF ACUTE MYELOID LEUKEMIA CELLS MEDIATED BY BONE MARROW STROMAL CELLS
294 IDENTIFICATION OF A NOVEL MECHANISM OF NPM1 CYTOPLASMIC LOCALIZATION IN ACUTE MYELOID LEUKEMIA: THE RECURRENT GENE FUSION NPM1–HAUS1
514 HEMORRHAGIC CYSTITIS CAUSED BY THE BK VIRUS DECREASES SURVIVAL POST-ALLOGENEIC STEM CELL TRANSPLANTATION
527 BLINATUMOMAB AS SOLE REINDUCTION AGENT FOR REFRACTORY PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA
662 THE USE OF HEPARIN PRIME FOLLOWED BY ACID-CITRATE-DEXTROSE-ADENINE (ACD-A) FOR EXTRACORPOREAL PHOTOPHERESIS (ECP) USING THE CELLEX ® INSTRUMENT.
04 Melanoma and Sarcoma 343 N‑ACETYL‑S‑(P‑CHLOROPHENYLCARBAMOYL)CYSTEINE, A NOVEL INHIBITOR OF THIOREDOXIN REDUCTASE, INDUCES MITOCHONDRIAL‑MEDIATED APOPTOSIS AND SUPPRESSES MIGRATION IN MELANOMA CELLS
524 IS PET-CT AN ACCURATE METHOD FOR THE DIFFERENTIAL DIAGNOSIS BETWEEN CHONDROMA AND CHONDROSARCOMA?
604 GUIDED SURGERY BY INFRARED LIGHT FOR SENTINEL LYMPH NODE LOCALIZATION IN CUTANEOUS MELANOMA
31 HYPERICIN INHIBITS MELANOMA BONE METASTASIS AND OSTEOLYSIS BY MODULATING THE TUMOR-BONE MICROENVIRONMENT
05 Breast 1 41 RECEPTOR CONVERSION AFTER NEOADJUVANT CHEMOTHERAPY IN BREAST CANCER PATIENTS
30 PROGNOSTIC SIGNIFICANCE OF THE PRETREATMENT PLATELET TO LYMPHOCYTE RATIO IN PATIENTS WITH TRIPLE-NEGATIVE BREAST CANCER
115 A PROGNOSTIC SIGNATURE BASED ON THREE-GENES EXPRESSION IN TRIPLE-NEGATIVE BREAST TUMOURS WITH RESIDUAL DISEASE
372 A MULTIDISCIPLINARY TEAM APPROACH TO EFFICIENT BREAST CANCER DIAGNOSIS
359 HER2-POSITIVE BREAST CANCER: IMPACT OF TARGET THERAPY ON SURVIVAL OF HISPANIC COHORT
46 TRANSLATOMICS IN INVASIVE BREAST CANCER: A BETTER COMPREHENSION FROM A TRANSLATION CONTROL PERSPECTIVE.
63 COPS5 AMPLIFICATION AND OVEREXPRESSION CONFERS ENDOCRINE RESISTANCE IN ER-POSITIVE BREAST CANCER BY DEGRADATION OF NCOR PROTEIN
117 FOXK2: A NOVEL ONCOGENE THAT IS AMPLIFIED AND OVER-EXPRESSED IN BREAST CANCER
06 Gastrointestinal 88 SIGNET RING CELL CARCINOMA OF THE ESOPHAGUS: A SEER DATABASE ANALYSIS
140 GENOMIC FEATURES OF PATIENT-DERIVED XENOGRAFTS OF GASTRIC CANCER AND TRANSFORMATION TO LYMPHOMA DURING ITS ESTABLISHMENT
491 EVALUATION OF H PYLORI IN PERUVIAN GASTRIC CANCER THROUGH RT- PCR
215 PROGNOSTIC AND PREDICT VALUE OF METASTATIC LYMPH NODE RATIO IN STAGE III GASTRIC CANCER AFTER D2 NODAL DISSECTION
82 LARGE SOLITARY HEPATOCELLULAR CARCINOMAS TREATED WITH TRANSARTERIAL CHEMOEMBOLIZATION: IN WHICH BCLC STAGE PATIENTS SHOULD BE ALLOCATED?
86 PATHOLOGIC DIAGNOSIS OF PANCREATIC ADENOCARCINOMA IN THE UNITED STATES: ITS STATUS AND PROGNOSTIC VALUE
64 WNT SIGNALING PROMOTES GASTRIC TUMORIGENESIS BY GALECTIN-3 MEDIATED ACTIVATION OF STAT3 PATHWAY
510 MPZL1 PROMOTES GASTRIC CANCER METASTASIS AND CHEMORESISTANCE THROUGH PARP1 AND CHK2 SIGNALINGS
07 Personalized Medicine 653 NK CELL THERAPY OF CANCER : ENHANCING FUNCTION BY HYPOXIC EDUCATION
85 IMPLEMANTATION OF A NEXT-GENERATION SEQUENCING-BASED GENE PANEL (ONCOPRIME) TO CANCER PATIENTS IN JAPAN
156 SIMPLIFIED INTERVENTIONAL MAPPING SYSTEM (SIMS): A NOVEL MULTIPLEX COMBINATORIAL COMPANION TEST AND STRATEGY TO MATCH PATIENT TO SINGLE DRUGS AND COMBINATIONS OF DRUGS
334 DETECTION OF ALK FUSION TRANSCRIPTS IN FFPE BRAZILIAN LUNG CANCER SAMPLES BY NANOSTRING TECHNOLOGY
505 COMPREHENSIVE GENOMIC PROFILING OF DESMOPLASTIC SMALL ROUND CELL TUMOR
619 KAPOSIFORM HEMANGIOENDOTHELIOMA: COULD SIROLIMUS REPLACE VINCRISTINE AS THE FIRST-CHOICE TREATMENT ?
08 Liquid Biopsy – Prognostic and Treatment Response 585 EXPRESSION OF MRP-2 IN CIRCULATING TUMOR CELLS (CTCS) OF PATIENTS WITH LOCALLY ADVANCED HEAD AND NECK SQUAMOUS CELL CARCINOMA (LAHNSCC) AND THEIR RELATION WITH PROGRESSION FREE SURVIVAL.
317 A PROSPECTIVE STUDY OF CIRCULATING TUMOR CELLS IN PATIENTS WITH RECTAL CANCER
649 PRION PROTEIN REGULATES THE SECRETION OF EXOSOMES MODULATING CAVEOLIN-1-SUPPRESSED AUTOPHAGY
584 EXPRESSION OF TGF-Β IN CIRCULATING TUMOR CELLS (CTCS) OF PATIENTS WITH LOCALLY ADVANCED HEAD AND NECK SQUAMOUS CELL CARCINOMA (LAHNSCC) AND THEIR RELATION WITH PROGRESSION FREE SURVIVAL.
439 LIQUID BIOPSY FOR MONITORING CHEMOTHERAPY RESPONSE IN WILMS TUMOR PATIENTS: SOMATIC TUMOR MUTATIONS IN URINE DNA BEFORE AND AFTER TREATMENT.
323 EVALUATION OF CIRCULATING TUMORAL MICROEMBOLI (CTM) AS A PROGNOSTIC FACTOR IN METASTATIC COLORECTAL CANCER PATIENTS
09 Hereditary tumors 370 GERMLINE BRCA1 AND BRCA2 MUTATIONS IN HIGH-RISK PATIENTS IN MEDELLIN, COLOMBIA
316 COMPLETION OF FOLLOW-UP AFTER ABNORMAL SCREENING TEST FOR LYNCH SYNDROME: A FRAMEWORK FOR MULTI-LEVEL CANCER CARE DELIVERY
630 COMPARATIVE ANALYSIS OF VARIANT OF UNCERTAIN SIGNIFICANCE IN BRCA1 AND BRCA2 AMONGST FOUR INSTITUTIONS
10 Radiation Oncology 58 DEVELOPING HYPERBRANCHED POLYGLYCEROL-BASED NANOPARTICLES FOR TARGETED DELIVERY OF RADIOSENSITIZERS
121 TRANSCRIPTOMIC CHANGES DURING CARBON ION RADIOTHERAPY OF PROSTATE CANCER PATIENTS DETECTED BY RNA-SEQ
132 UNI-INSTITUTIONAL LONG TERM RESULTS OF HIGH DOSE RATE BRACHYTHERAPY COMBINED TO EXTERNAL BEAM RADIOTHERAPY FOR LOCAL AND LOCALLY ADVANCED PROSTATE CANCER
266 THE CORRELATION BETWEEN AEG-1 EXPRESSION AND RADIO-SENSITIVITY AND PROGNOSIS IN NON-SMALL CELL LUNG CANCER
498 RADIOTHERAPY IN THE TREATMENT OF CHORDOMA.
558 COMPUTER-BASED INTRA AND INTER-OBSERVER SEGMENTATION CORRELATION FOR BRAIN METASTASIS: EVALUATION OF POTENTIAL SYSTEMATIC ERROR IMPROVEMENT.
11 Gynecologic Cancers 136 BINDING OF GALECTIN-1 TO CA125 PROMOTED TUMOR INVASION AND PROGRESSION IN OVARIAN CANCER
406 LOCOREGIONAL RECURRENCE OF GYNECOLOGIC CANCER: WHAT IS THE ROLE OF MRI?
565 PUTATIVE MIRNAS REGULATORS OF HMGA2 IN UTERINE LEIOMYOMAS AND ITS ASSOCIATION WITH MED12 MUTATION
296 ABLATION TECHNIQUES ADAPTED FOR LOW- AND MIDDLE-INCOME COUNTRIES
279 MIDAS: A PRACTICAL BAYESIAN DESIGN FOR PLATFORM TRIALS WITH IMMUNOTHERAPY AGENTS
427 AN EVALUATION OF NFKB EXPRESSION PROTEIN IN PATIENTS WITH OVARIAN SEROUS CARCINOMA IN NON-SENSITIVE GROUP TO CHEMOTHERAPY.
12 Diagnostic Imaging 148 RADIOEMBOLIZATION OF PRIMARY AND SECONDARY HEPATIC MALIGNANCIES
376 EVALUATION OF OSTEOSARCOMA RESPONSE TO RADIUM-223 TREATMENT USING BONE SCINTIGRAPHY, NAF-PET, AND FDG-PET
152 PREDICTIVE EFFICACY OF 11C-PD153035 PET IMAGING FOR EGFR–TYROSINE KINASE INHIBITOR SENSITIVITY IN NON-SMALL CELL LUNG CANCER PATIENTS
143 DESCRIPTION AND CLINICAL IMPLICATIONS OF INCIDENTALLY-FOUND LESIONS ON CONE-BEAM CT ANGIOGRAPHY DURING TACE/TAE IN PATIENTS WITH METASTATIC TUMORS
660 DOES REDUCED FIELD OF VIEW DIFFUSION SEQUENCE HAS THE ABILITY IN ASSESSING MICROSATELLITE INSTABILITY? AN INITIAL EXPERIENCE
626 QUANTITATIVE IMAGING OF THORACIC MALIGNANCIES
425 INFLUENCE OF FASTING ON CONTRAST-ENHANCED CT SCANS IN A CANCER CENTER.
560 DOES PATHOLOGICAL FEATURES AFFECTS THE AGREEMENT BETWEEN MRI AND PATHOLOGIC TUMOR SIZE ON INVASIVE BREAST CARCINOMAS?
13 Lung 494 THE IMPORTANCE OF THORACIC RADIOTHERAPY AND RADIATION DOSE ON THE PROGNOSIS OF EXTENSIVE STAGE SMALL CELL LUNG CANCER
155 CLINICAL EVALUATION OF AN IMPROVED METHOD FOR EPIDERMAL GROWTH FACTOR RECEPTOR MUTATION DETECTION
302 CORRELATION OF NEUROENDOCRINE DIFFERENTIATION FEATURES WITH PROGNOSIS OF NON SMALL CELL LUNG CANCER IN CHINESE POPULATION
49 REQUIREMENTS AND IMPLEMENTATION OF LUNG SBRT PROGRAM IN DEVELOPING COUNTRIES : BENEFIT OF INTERNATIONAL COOPERATION MDACC & KHCC AS AN EXAMPLE
536 ABSTRACT MINIMALLY INVASIVE SURGICAL STRATEGIES IN THE FIRST BRAZILIAN LUNG CANCER SCREENING TRIAL (BRET1)
555 LUNG CANCER SCREENING IN THE US
623 BUILDING A LUNG CT SCREENING PROGRAM AS A MODEL FOR RESEARCH,EDUCATION AND HEALTH CARE
456 VIDEO ASSISTED THORACOSCOPIC SURGERY (VATS) PULMONARY WEDGE RESECTION WITHOUT POST-OPERATIVE CHEST DRAIN
14 Population Science & Cancer Epidemiology 367 BUILDING CAPACITY FOR CANCER CONTROL: THE GLOBAL INITIATIVE FOR CANCER REGISTRY DEVELOPMENT
500 HISTORICAL ANALYSIS OF THE BRAZILIAN CERVICAL CANCER SCREENING PROGRAM FROM 2006 TO 2013: A TIME FOR REFLECTION
602 SIGNIFICANT DIFFERENCES IN DEMOGRAPHIC AND CLINICOPATHOLOGICAL CHARACTERISTICS BETWEEN PATIENTS WITH BLADDER CANCER FROM AN ARSENIC-EXPOSED REGION AND FROM TWO REFERENCE SITES: A COMPARATIVE STUDY
189 TRENDS IN LOCAL THERAPY UTILIZATION AND COST FOR EARLY-STAGE BREAST CANCER IN OLDER AMERICAN WOMEN: IMPLICATIONS FOR POPULATION HEALTH MANAGEMENT
87 IMPACT OF MARITAL STATUS ON SURVIVAL OF GASTRIC ADENOCARCINOMA PATIENTS: RESULTS FROM THE SURVEILLANCE EPIDEMIOLOGY AND END RESULTS (SEER) DATABASE.
101 FATIGUE, QUALITY OF LIFE AND RELATED SYMPTOMS: PATIENT REPORTED OUTCOMES IN MYELODYSPLASTIC SYNDROME
434 LEUKOCYTE TELOMERE LENGTH AND PROGNOSIS OF LOCALIZED PROSTATE CANCER
454 GLOBAL AND GENE-SPECIFIC PROMOTER METHYLATION CHANGES AND MICRONUCLEI LEVELS IN CONSTRUCTION WORKERS EXPOSED TO ENVIRONMENTAL CARCINOGENS
391 BIOBANK ACCESS POLICY THAT BOOSTS THE CANCER CENTER BIOSAMPLE USAGE AND ELEVATES THE INSTITUTIONAL RESEARCH LEVEL
15 Survivorship 165 HOW WILL CANCER SURVIVORS USE SURVIVORSHIP CARE PLANS (SCPS)?
277 TOBACCO USE AMONG LYMPHOMA SURVIVORS
278 USING CLINICAL ALGORITHMS TO IDENTIFY PSYCHOSOCIAL DISTRESS AND OTHER RISK FACTORS IN CANCER SURVIVORS
314 PRIMARY HEALTH CONCERNS PERCEIVED BY LONG-TERM DISEASE-FREE COLORECTAL CANCER SURVIVORS: A QUALITATIVE ANALYSIS
426 EFFECT OF HEALTH CARE INSURANCE ON SURVIVAL IN PATIENTS WITH SURGICAL TREATMENT FOR BREAST CANCER IN A CANCER CENTER IN MEDELLÍN-COLOMBIA: A HISTORICAL COHORT STUDY
525 IMAGING STUDIES DURING SURVIVORSHIP AFTER LYMPHOMA TREATED WITH CURATIVE INTENT
16 Ovarian 150 IDENTIFICATION OF CANDIDATE GENES FOR GRANULOSA CELL TUMOR PROGRESSION
211 MIR-211 REGULATES OVARIAN CANCER MALIGNANCY BY TARGETING CYCLIN D1 AND CDK6
435 DOWN-REGULATED EXPRESSION OF MICRORNAS IN HIGH GRADE SEROUS OVARIAN CANCER OF PATIENTS WITH DIFFERENT CLINICAL OUTCOMES
17 Neuro Oncology 337 THE SURGEON MAY BE AIDED IN THE DELICATE ONCO-FUNTIONAL BALANCE IN RESECTION OF MALIGNANT GLIOMAS BY THE COMBINED USE OF 5-ALA AND AWAKE CRANIOTOMY WITH CORTICAL AND SUBCORTICAL MAPPIPING
112 ESTABLISHING THE ROLE OF ARGININE DEPRIVATION IN CANCER TREATMENT THROUGH PRE-CLINICAL ACTIVITY OF THE RECOMBINANT HUMAN ARGINASE PEG-BCT-100 IN GLIOMAS AND SOFT-TISSUE SARCOMAS (STS)
204 QKI DELETION ENHANCES SELF-RENEWAL OF GLIOMA STEM CELLS AND PROMOTES GLIOMAGENESIS
207 C-FOS OVER-EXPRESSION PROMOTES RADIORESISTANCE AND PREDICTS POOR PROGNOSIS IN MALIGNANT GLIOMA
71 TREATMENT OF RECURRENT MALIGNANT GLIOMA WITH BCNU-LOADED BIODEGRADABLE IMPLANTS: EXPERIENCE OF 22 CHINESE CASES
96 OVEREXPRESSION OF TEAD4 IN AT/RT; NEW INSIGHT TO THE PATHOPHYSIOLOGY OF AN AGGRESSIVE BRAIN TUMOR
145 Β-ELEMENE INDUCES CASPASE-DEPENDENT APOPTOSIS IN HUMAN GLIOMA CELLS IN VITRO THROUGH THE UPREGULATION OF BAX AND FAS/FASL AND DOWNREGULATION OF BCL-2
151 THERAPEUTIC EFFECTS OF THIADIAZOLE DERIVATIVES ON GLIOBLASTOMA CELL LINES.
455 COPY NUMBER PROFILING OF BRAZILIAN ASTROCYTOMAS
18 Anesthesiology 459 MULTIMODAL ANALGESIC TREATMENT IN VIDEO-ASSISTED THORACIC SURGERY LOBECTOMY USING AN INTRAOPERATIVE INTERCOSTAL CATHETER
73 A RETROSPECTIVE REVIEW OF FACTORS ASSOCIATED WITH CORNEAL ABRASIONS AFTER ONCOLOGIC SURGERY IN A TERTIARY CANCER CENTER
380 FUNCTIONALITY AND END-USER ACCEPTABILITY OF THE INTERNET-BASED COMPUTERIZED PATIENT ASSESSMENT SYSTEM (ICOMPASS), A MOBILE SYMPTOM MONITORING SYSTEM
19 Critical Care 492 ONCOLOGIC EMERGENCIES
424 INTRA ABBDOMINAL PRESSURE MONITORING ADMITTED TO THE INTENSIVE CARE UNIT
645 TRANSFUSION IN OLDER PATIENTS WITH CANCER ADMITTED TO THE INTENSIVE CARE UNIT
20 Cancer Prevention and early diagnosis 60 SCREENING AND EARLY DETECTION OF UTERINE CERVIX CANCERS USING VISUAL BASED SCREENING METHODS IN INDIA
528 CHANGING A NATIONAL CERVICAL CANCER SCREENING PROGRAM: RANDOMIZED IMPLEMENTATION OF PRIMARY HPV TESTING IN NORWAY
591 COLORECTAL CANCER SCREENING IN BARRETOS CANCER HOSPITAL, BRAZIL: INITIAL RESULTS FROM A PILOT IMPLEMENTATION PROGRAM
605 UNDERSTANDING ECONOMIES OF SCALE, SCOPE AND KNOWLEDGE AND THEIR IMPORTANCE TO SUCCESSFUL HEALTHCARE DELIVERY ORGANIZATIONS
56 “TELL ME EVERYTHING…ABOUT CANCER” COMMUNITY INTERVENTION TO CLARIFY MYTHS AND TRUTHS OF CANCER
262 SKIN CANCER SCREENING VIA TELEDERMATOLOGY: EXPERIENCE IN THE STATE OF SANTA CATARINA
21 Head & Neck 482 TREATMENT OF MAXILLOMANDIBULAR DEFECTS USING CUSTOM-MADE IMPLANTS WITH VASCULARIZED FIBULAR GRAFT
263 EXPERIENCE IN THE USE OF SENTINEL LYMPH NODE IN EARLY ORAL CANCER
51 PREDICTING THE SHORT-TERM RESPONSE TO CHEMORADIOTHERAPY USING INTRAVOXEL INCOHERENT MOTION DIFFUSION-WEIGHTED AND DYNAMIC CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING IN PATIENTS WITH NASOPHARYNGEAL CARCINOMA
84 LONG-TERM OUTCOME OF LARYNGEAL FRAMEWORK RECONSTRUCTION USING TITANIUM MESH IN GLOTTIC CANCER AFTER FRONTOLATERAL VERTICAL PARTIAL LARYNGECTOMY
139 SIGNIFICANCE OF VOLUMETRIC STAGING AND MOLECULAR PROFILES IN RADIOTHERAPY FOR H&N CANCER
206 RELATIONSHIP BETWEEN POLYMORPHISMS IN GLUCOSE GLYCOLYTIC PATHWAY ASSOCIATED GENES AND RISK OF NASOPHARYNGEAL CARCINOMA DEVELOPMENT
22 Breast 2 34 ANDROGEN RECEPTOR EXPRESSION PREDICTS DIFFERENT CLINICAL OUTCOMES FOR BREAST CANCER PATIENTS STRATIFIED BY HORMONE RECEPTOR STATUS.
149 ASTROCYTE-DERIVED EXOSOMAL MIR-19A REVERSIBLY DOWNREGULATES PTEN EXPRESSION IN CANCER CELLS TO PROMOTE BRAIN METASTASIS OUTGROWTH
120 STUDY ON DETECTION OF CIRCULATING TUMOR DNA IN BREAST CANCER
407 CHARACTERIZATION OF THE TRANSCRIPTIONAL LANDSCAPE OF CIRCULATING EXTRACELLULAR VESICLES IN HER-2+ BREAST CANCER PATIENTS